I have seen plenty of casemods over the years and some of them are cooler than others. Generally, we see a case that started life as a normal computer chassis that the modder added things to turn it into something else entirely.
There are lots of reasons that a person might need to control their computer with one hand, and not all of them have to do with self-gratification. Being able to control a computer with one hand is a great thing in a small workspace or if you are standing up and need to hold a notebook or tablet.
The tablet market is scorching hot today with many of the new offerings showing up with Android on board. There is a place for tablets that run Windows too, especially in the business and medical communities.